Dr. Jacob's Vitamin D3K2 Oil forte 20 ml

Highly Dosed Vitamin D₃K₂ Drops

2000 IU (50 µg) Vitamin D₃ + 50 µg Vitamin K₂ (all-trans MK-7) per drop

✓ Made in Germany with Vitamin D₃ + K₂ from Europe in pharmacopoeia quality
✓ Optimally bioavailable and stable thanks to natural vitamin E
✓ Good for bones, muscles, and immune system*
✓ Expertise + Experience: first Vitamin D₃K₂ oil in German pharmacies (since 2015), Forte oil since 2018
✓ Excellent price-dose ratio: 640 drops, vegetarian

20 ml (640 drops)

Why do we need the combination of Vitamin D₃ and K₂?

Vitamin D is essential for maintaining bones and teeth, muscle function, and the immune system, and plays a role in cell division. For the maintenance of normal bones, it works closely with Vitamin K: Vitamin D₃ stimulates the production of osteocalcin, which is activated by Vitamin K₂ to efficiently deposit calcium into the bones.

Vitamin K₂ is hardly absorbed through diet. Dr. Jacob's Vitamin D₃K₂ Oil forte contains long-chain Vitamin K₂ (menaquinone as all-trans MK-7) with high bioavailability and stability. It remains in the body for up to three days, about 50 times longer than Vitamin K₁.

Only 12% have good Vitamin D₃ levels; in winter, it's under 5%

Diet contributes little to vitamin D supply; UVB sunlight is crucial for endogenous synthesis in the skin. A deficiency is particularly common in winter, but even in summer, factors like sunscreen or a dark skin type can inhibit vitamin D synthesis. Studies show that endogenous production is often insufficient even in summer:

On an annual average, only 12% of the German population achieve the vitamin D level of over 75 nmol/l (1,2) recommended by leading scientists; in winter, this figure drops to less than 5%. Only 38% of Germans consistently reach the lower threshold of at least 50 nmol/l set by the German Nutrition Society (DGE) throughout the year.(3)

Experts also disagree on the correct intake recommendation. This actually depends on many factors: baseline value, age, weight, sun exposure, skin color, etc. The DGE recommends a serum value of at least 50 nmol/l and a daily intake of 800 IU (20 µg) vitamin D (from 2 years of age, in case of insufficient endogenous synthesis).

The renowned American Geriatrics Society recommends that all individuals aged 70 and older consume 4000 IU (100 µg) of vitamin D daily (from all sources) to maintain a good serum level of at least 75 nmol/l. This corresponds to the daily intake deemed safe (tolerable) by the European Food Safety Authority (EFSA) for individuals aged 11 and older.

(1)Holick et al. J Clin Endocrinol Metab (2011) 96(7):1911-30. (2)Bischoff-Ferrari et al. Am J Clin Nutr (2006) 84(1):18-28. (3)Rabenberg et al. BMC Public Health (2015) 15:641; Good Vitamin D level ≥ 75 nmol/l 25(OH)D, according to Holick et al. J Clin Endocrinol Metab (2011) 96(7):1911-30.

Who should pay particular attention to their vitamin D level?

• Everyone during months with low UV radiation (October to March)

• People who spend most of their time indoors or cover their skin

• Users of sunscreens (SPF 10 reduces vitamin D production by 90%)

• People with dark skin types

• Pregnant women, breastfeeding mothers, babies, and toddlers

• Women during/after menopause

• Overweight individuals

• Seniors

A vitamin D blood test (at the doctor's, in the pharmacy, or a self-test) can provide clarity.

Dr. Jacob's Vitamin D₃K₂ Oil forte – Vitamin Oil for Bones and Immune System*

*The vitamins contained in Dr. Jacob's Vitamin D₃K₂ Oil forte contribute to the following normal bodily functions:

• Maintenance of bones – Vitamin D and K

• Maintenance of teeth – Vitamin D

• Maintenance of muscle function – Vitamin D

• Immune system – Vitamin D

• Plays a role in cell division – Vitamin D

• Normal absorption and utilization of calcium – Vitamin D

• Normal blood clotting – Vitamin K

• Reduction of fall risk** – Vitamin D

**In women and men aged 60 and over, falls represent a risk factor for bone fractures. The increased risk of falls in old age may be related to vitamin D supply. Daily intake of 800 IU (20 µg) vitamin D from all sources contributes to the reduction of fall risk in people aged 60 and over, which is associated with muscle weakness and physical instability. Falls are caused by several risk factors. A change in one of these risk factors may or may not show a positive effect.

Proven quality at a fair price

Already in 2015, Dr. Jacob's was the first manufacturer to introduce a Vitamin D₃K₂ oil into German pharmacies. This was later followed by the higher-dosed Vitamin D₃K₂ Oil forte. Both oils are still produced in Germany today. The vitamins used are of pharmacopoeial quality and sourced from Europe.

One bottle contains 640 drops with 50 µg (2000 IU) D₃ + 50 µg K₂ (all-trans MK-7) per drop.

What is special about Vitamin K₂ Menaquinone-7?

Dr. Jacob’s vitamin oils provide vitamin K₂ in the form of menaquinone-7 (all-trans MK-7). This form can be absorbed and utilized by the body particularly well compared to vitamin K₁ and other K₂ forms. Thanks to its high stability, about half of the vitamin is still detectable in the blood after three days, while for vitamin K₁, the half-life is only 1.5 hours (Schurgers et al., 2007).

The Vitamin K₂ Menaquinone-7 we use comes from Europe and is particularly pure and effective*. It contains almost 100% of the active, natural form of Vitamin K₂, the so-called trans-form.

For comparison: analyses of common vitamin K₂ raw materials from China showed unknown chemical impurities of 88–90%. Lower quality vitamin K₂ contains, in addition to the biologically active trans-form, a high proportion of the biologically inactive cis-form.

Natural Vitamin E and MCT oil for optimal protection and stability

Vitamins D₃ and K₂ are very sensitive to oxidation. Dr. Jacob's Vitamin D₃K₂ Oil forte therefore contains natural Vitamin E (tocopherols) as an antioxidant in the optimal dosage. This is crucial, as both too little and too much Vitamin E can accelerate the degradation of Vitamins D₃ and K₂. The correct amount ensures the vitamin content until the best-before date. Regular analyses confirm the long-term stability of the vitamin content.

Additionally, high-quality MCT oil from coconut oil protects the sensitive vitamin and improves its absorption in the body. Medium-chain triglycerides (MCTs) are more stable than long-chain fatty acids, such as those found in olive oil, and thus offer better protection against oxidation.

Dr. Jacob's vitamin oils benefit from the manufacturer's many years of experience – a characteristic that imitators lack.

Best interplay: The ideal partners of Vitamin D

Not only Vitamin D₃ contributes to the maintenance of normal bones, but also Vitamin K₂. Both work synergistically and should ideally be taken in combination.

Calcium metabolism is closely intertwined with magnesium and potassium. Magnesium supports the maintenance of normal bones and the normal function of nerves and muscles. Potassium contributes to the normal function of muscles and the nervous system, as well as to the maintenance of normal blood pressure. According to NVS2, a deficiency in these minerals is common (4).

(4)National Consumption Study 2 (MRI 2008).